Wnt glycoproteins are signaling molecules that control a wide range of developmental processes in organisms ranging from the simple metazoan Hydra to vertebrates. Wnt signaling also plays a key role in the development of the nematode C. elegans, and is involved in cell fate specification and determination of cell polarity and cell migration. Surprisingly, the first genetic studies of Wnt signaling in C. elegans revealed major differences with the established (canonical) Wnt signaling pathways of Drosophila and vertebrates. Thus, the Wnt-dependent (...) induction of endoderm in the early embryo and the specification of several asymmetric cell divisions during larval development are mediated by as yet novel Wnt signaling pathways that repress, rather than activate the TCF/LEF-1 transcription factor POP-1. Recently, however, it has been shown that, in addition to these divergent Wnt pathways, C. elegans also has a canonical Wnt pathway that converts POP-1 into an activator and controls the expression of several homeobox genes. Interestingly, these different Wnt pathways use distinct beta-catenins to control POP-1 function: the endoderm induction pathway requires the beta-catenin WRM-1 and parallel input from a mitogen-activated kinase (MAPK) pathway to downregulate POP-1, whereas the canonical Wnt pathway employs the beta-catenin BAR-1 to activate Wnt target gene expression. (shrink)

This contribution is a review article on the three most important books by F. Gerrit Immink in practical theology. His approach to this discipline is studying faith praxis of the Protestantse Kerk in Nederland which is a church in the Reformed tradition. In his first book he explained his approach to practical theology in a discussion with the action theory and hermeneutical-communucative approaches. His choice for the study of faith praxis opens the way for a more theological approach to him (...) in which communication between God and people is an important aspect. His second book forms the central part of this article. He uses the concept performance in the liturgy which is adopted from the theater world. In the performance by means of the execution of the liturgy by the congregation they all get involved in the message from the Bible of that Sunday, they are touched by it, it has an effect on them, and they get a new perspective on the problems of everyday life. This is possible through the work of the Holy Spirit. The epiclese prayers in the liturgy are prayers for the enlightening and work by the Spirit. He discusses singing, praying, preaching, baptism and Holy Communion in detail. The main idea is that the performance in the liturgy does something to you, it has an effect on you, something happens to you. To my mind there is no need to choose between the ritual approach and the approach he is putting on the table. The approaches can enrich each other. (shrink)

The search for a good method to analyse sermon content has been prevailing since the past decades to evaluate current practice so as to construct better theories for practice. I think that we have found it in the methodology of inductive, qualitative research of the Grounded Theory methodology. In this article, I am going to use the Grounded Theory approach to describe the phases of qualitative empirical research, namely, literature study, sampling, open coding of the data, selective coding of additional (...) new data and theoretical coding to be able to construct an emerging theory of praxis using the concepts developed for this specific action in our discipline. There are critical comments for this methodology. I will try to address these critical views and argue that the Grounded Theory is in line with the science of research. (shrink)

Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecendented in its combination of biology with a ...

Looking Beneath the Surface explores Arab-Islamic and Western perspectives on medical ethical issues: genetic research and treatment, abortion, organ donation, and palliative sedation and euthanasia. The contributions in this volume discuss the state of the art, the role of laws, counseling, and spiritual counseling in the decision-making process. The different approaches to the ethical issues, ways of moral reasoning, become clear in these contributions, especially the role of tradition for Islam and the importance of autonomy for the West. Beneath the (...) differences, however, the reader will also discover common values, such as the role of dignity and the value of life, and similar practices. Some of the main differences are sociocultural in nature, rather than religious as such. Well-known experts in the fields of medicine and ethics have contributed to this volume from different religious and secular backgrounds. The book offers a carefully written introduction and final chapter on intercultural comparisons. Looking Beneath the Surface is more than a collection of writings on issues in medical ethics: it helps the reader to compare different paradigms of accountability and moral reasoning. (shrink)

The Netherlands does not have any specific legislation pertaining to human biological materials and data collection by biobanks. Instead, these issues are governed by a patchwork of laws, codes of practices, and other ethical instruments, where special emphasis is given to the right to privacy and self-determination. While draft legislation for biobanking was scheduled to enter into force in 2007, as of mid-2015 such legislation was still under consideration, with the intent that it would focus particularly on individual self-determination, the (...) interests of research, the use of bodily materials collected by biobanks for criminal law purposes, and dilemmas around results that are clinically relevant for biobank participants. Under the current framework, the amount of privacy protection afforded to data is linked to its level of identifiability. International sharing of personal data to non-EU/European Economic Area countries is allowed if these countries provide adequate protection. (shrink)

About one third of patients with epilepsy have seizures refractory to the medical treatment. Electrical stimulation mapping is the gold standard for the identification of “eloquent” areas prior to resection of epileptogenic tissue. However, it is time-consuming and may cause undesired side effects. Broadband gamma activity recorded with extraoperative electrocorticography during cognitive tasks may be an alternative to ESM but until now has not proven of definitive clinical value. Considering their role in cognition, the alpha and beta bands could further (...) improve the identification of eloquent cortex. We compared gamma, alpha and beta activity, and their combinations for the identification of eloquent cortical areas defined by ESM. Ten patients with intractable focal epilepsy participated in a delayed-match-to-sample task, where syllable sounds were compared to visually presented letters. We used a generalized linear model approach to find the optimal weighting of each band for predicting ESM-defined categories and estimated the diagnostic ability by calculating the area under the receiver operating characteristic curve. Gamma activity increased more in eloquent than in non-eloquent areas, whereas alpha and beta power decreased more in eloquent areas. Diagnostic ability of each band was close to 0.7 for all bands but depended on multiple factors including the time period of the cognitive task, the location of the electrodes and the patient’s degree of attention to the stimulus. We show that diagnostic ability can be increased by 3–5% by combining gamma and alpha and by 7.5–11% when gamma and beta were combined. We then show how ECoG power modulation from cognitive testing can be used to map the probability of eloquence in individual patients and how this probability map can be used in clinical settings to optimize ESM planning. We conclude that the combination of gamma and beta power modulation during cognitive testing can contribute to the identification of eloquent areas prior to ESM in patients with refractory focal epilepsy. (shrink)

Individuals with cerebral palsy (CP) have deficits in processing of somatosensory and proprioceptive information. To compensate for these deficits, they tend to rely on vision over proprioception in single plane upper and lower limb movements and in standing. It is not known whether this also applies to walking, an activity where the threat to balance is higher. Through this study, we used visual perturbations to understand how individuals with and without CP integrate visual input for walking balance control. Additionally, we (...) probed the balance mechanisms driving the responses to the visual perturbations. More specifically, we investigated differences in the use of ankle roll response i.e., the use of ankle inversion, and the foot placement response, i.e., stepping in the direction of perceived fall. Thirty-four participants (17 CP, 17 age-and sex-matched typically developing controls or TD) were recruited. Participants walked on a self-paced treadmill in a virtual reality environment. Intermittently, the virtual scene was rotated in the frontal plane to induce the sensation of a sideways fall. Our results showed that compared to their TD peers, the overall body sway in response to the visual perturbations was magnified and delayed in CP group, implying that they were more affected by changes in visual cues and relied more so on visual information for walking balance control. Also, the CP group showed a lack of ankle response, through a significantly reduced ankle inversion on the affected side compared to the TD group. The CP group showed a higher foot placement response compared to the TD group immediately following the visual perturbations. Thus, individuals with CP showed a dominant proximal foot placement strategy and diminished ankle roll response, suggestive of a reliance on proximal over distal control of walking balance in individuals with CP. (shrink)

Moreover, he is known to be an extremely gifted lecturer, who is able to set forth ethical issues very lucidly. erudition and profundity are also evident in the ...

In Intolerance, Polemics, and Debate in Antiquity scholars reflect on politico-cultural, philosophical, and religious forms of critical conversation in the ancient Near Eastern, Biblical, Graeco-Roman, and early-Islamic world. They enquire into the boundaries between debate, polemics, and intolerance, and address their manifestations in both philosophy and religion. This cross-cultural and inclusive approach shows that debate and polemics are not so different as often assumed, since polemics may also indicate that ultimate values are at stake. Polemics can also have a positive (...) effect, stimulating further cultural development. Intolerance is more straightforwardly negative. Religious intolerance is often a justification for politics, but also elite rationalism can become totalitarian. The volume also highlights the importance of the fluency of minorities in the dominant discourses and of their ability to develop contrapuntal lines of thought within a common cultural discourse. Contributors are: Robbert van den Berg, Stefan Beyerle, George Boys-Stones, Reuven Firestone, Pieter B. Hartog, Paul Heck, Paulin Ismard, George van Kooten, Marjo C. Korpel, Dominik Markl, Steve Mason, Peter Franz Mittag, James C. Oleson, James Carleton Paget, Lautaro Roig Lanzillotta, Jacques van Ruiten, Diego R. Sarrió Cucarella, Clare Wilde. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Varieties of Vernacular Mysticism (1350–1550) by Bernard McGinnDennis J. Billy C.Ss.R.The Varieties of Vernacular Mysticism (1350–1550). By Bernard McGinn. New York: Crossroad, 2012. Pp. xiv + 721. $70.00 (cloth). ISBN: 978-0-8245-9901-0.This fifth volume of McGinn’s Presence of God: A History of Western Christian Mysticism covers the Dutch, Italian, and English vernacular mystics of the late Middle Ages. In previous volumes, the author treated the Foundations (vol. 1), (...) Growth (vol. 2), Flowering (vol. 3), and Harvest (vol. 4) of Western Christian mysticism from its roots in the Jewish matrix and the Greek ideal to its fruition in the German vernacular writings of Meister Eckhart and his students. In this latest volume, he continues his history of Western Christian mysticism by focusing on varieties of vernacular mysticism in the Low Countries, Italy, and England from 1350 to 1550.Conscious of the dangers of historical periodization and regional classification, as well as the relationship of mysticism to the greater ecclesiastical world, McGinn takes pains to show the distinctive character of each mystic under consideration, while at the same time pointing out appropriate parallels with Western and Eastern Christian mystics from past historical epochs and those contemporary voices from both within and [End Page 476] without each mystic’s linguistic region. In his preface, he apologizes to his readers for the long gestation of the present volume and offers a brief account of how his original plan of writing a three-volume history of Western Christian mysticism evolved into a series of seven, due in large part to the sheer wealth of sources and his desire to give them a thorough treatment. Rather than following his original intention of including other vernacular traditions in his previous volume on German mysticism, he wisely chose to devote an entire volume to these other important strands (ix–x).Instead of writing a general introduction to the volume, McGinn decides to give a brief introduction to each of the three major parts. He divides his work into thirteen chapters constructed along the following lines: (1) “Late Medieval Mysticism in the Low Countries” (chaps. 1–5), (2) “Mysticism in Late Medieval Italy” (chaps. 6–9), and (3) “Mysticism in Late Medieval England” (chaps. 10–13). The volume closes with a brief conclusion (491–94), extended annotations (495–661), an extensive bibliography (662–704), and indices for Scripture references (705–6), names (707–12), and subjects (713–21). The book’s organization reflects the theme of diversity highlighted in its title. Although each part has its own internal structure and stands on its own as a survey of the material at hand, it also fits well into the volume’s overall plan of pointing out the distinctiveness and great variety of the vernacular mysticisms produced during this period. Taken individually, each part can be considered a probing monograph on the vernacular mysticism in each region. Taken together, the parts offer a unique glimpse into the mystic and literary creativity that sets this period apart as one of the most fertile periods in the history of Christian mysticism.In part 1, “Late Medieval Mysticism in the Low Countries,” McGinn notes that “the period ca. 1350 to ca. 1550 is the central era for Dutch mysticism” and “witnessed a florescence of mystical authors writing in the Dutch-Flemish language” (1). Although he hesitates to refer to a Dutch “school” of mysticism and thinks that “Ruusbroec should not be made the yardstick by which all later Dutch mystics are measured,” he has no reservations about considering him “a gravitational center in the history of Dutch mysticism” (2). This section of the book begins with an in-depth look at the mystical writings of Jan van Ruusbroec (1293–1381) (chap. 1) and continues with a study of Goenendaal mysticism after Ruusbroec (chap. 2). It then turns to a treatment of the mystical aspects of the Devotio Moderna, with a special emphasis on The Imitation of Christ and some vernacular mystics numbered among the Devout, such as Hendrik Mande (ca. 1360–1431, Gerlach Peters (ca. 1375–1411), and Alijt Bake (1415–55), and adds a brief note on the nominalistic... (shrink)

The relationship between Albert Einstein’s special theory of relativity and Hendrik A. Lorentz’s ether theory is best understood in terms of competing interpretations of Lorentz invariance. In the 1890s, Lorentz proved and exploited the Lorentz invariance of Maxwell’s equations, the laws governing electromagnetic fields in the ether, with what he called the theorem of corresponding states. To account for the negative results of attempts to detect the earth’s motion through the ether, Lorentz, in effect, had to assume that the (...) laws governing the matter interacting with the fields are Lorentz invariant as well. This additional assumption can be seen as a generalization of the well-known contraction hypothesis. In Lorentz’s theory, it remained an unexplained coincidence that both the laws governing fields and the laws governing matter should be Lorentz invariant. In special relativity, by contrast, the Lorentz invariance of all physical laws directly reflects the Minkowski space-time structure posited by the theory. One can use this observation to produce a common-cause argument to show that the relativistic interpretation of Lorentz invariance is preferable to Lorentz’s interpretation. (shrink)

"This edition, which replaces the original Loeb edition..., offers text, translation, and annotation that are fully current with modern scholarship"--Front flap of dust jacket, volume 1.

Is there such a thing as natural knowledge of God? C. Stephen Evans presents the case for understanding theistic arguments as expressions of natural signs in order to gain a new perspective both on their strengths and weaknesses. Three classical, much-discussed theistic arguments - cosmological, teleological, and moral - are examined for the natural signs they embody. At the heart of this book lie several relatively simple ideas. One is that if there is a God of the kind accepted by (...) Christians, Jews, and Muslims, then it is likely that a 'natural' knowledge of God is possible. Another is that this knowledge will have two characteristics: it will be both widely available to humans and yet easy to resist. If these principles are right, a new perspective on many of the classical arguments for God's existence becomes possible. We understand why these arguments have for many people a continued appeal but also why they do not constitute conclusive 'proofs' that settle the debate once and for all. Touching on the interplay between these ideas and contemporary scientific theories about the origins of religious belief, particularly the role of natural selection in predisposing humans to form beliefs in God or gods, Evans concludes that these scientific accounts of religious belief are fully consistent, even supportive, of the truth of religious convictions. (shrink)

This paper evaluates several recent efforts to interpret the work of Nāgārjuna through the lens of modern symbolic logic. An attempt is made to uncover the premises that justify the use of symbolic logic for this purpose. This is accomplished through a discussion of (1) the historical origins of those premises in the Indian and Tibetan traditions, and (2) how such assumptions prejudice our understanding of Nāgā rjuna’s insistence that he has no “proposition” (pratijñā). Finally, the paper sets forth an (...) alternative interpretation that takes into account the literary dimensions of Nāgārjuna’s writing. (shrink)

In this paper, we provide a logical formalization of the emotion triggering process and of its relationship with mental attitudes, as described in Ortony, Clore, and Collins’s theory. We argue that modal logics are particularly adapted to represent agents’ mental attitudes and to reason about them, and use a specific modal logic that we call Logic of Emotions in order to provide logical definitions of all but two of their 22 emotions. While these definitions may be subject to debate, we (...) show that they allow to reason about emotions and to draw interesting conclusions from the theory. (shrink)

C A Wringe; Reply to Antony Flew, Journal of Philosophy of Education, Volume 13, Issue 1, 30 May 2006, Pages 149–158, https://doi.org/10.1111/j.1467-9752.1979.t.

There is the world of ideas and the world of practice; the French are often for sup pressing the one and the English the other; but neither is to be suppressed. -Matthew Arnold The Function of Criticism at the Present Time From its inception, bioethics has confronted the need to reconcile theory and practice. At first the confrontation was purely intellectual, as writers on ethical theory (within phi losophy, theology, or other humanistic disciplines) turned their attention to topics from the (...) world of medical practice. Recently the confrontation has grown more intense. The ap pointment of clinical ethicists in hospitals and other health care settings is an accelerating trend in North America. Concomitantly, those institutions involved in training peo ple in clinical ethics have added organized exposure to the world of practice, in the form of placement requirements, to the normal academic course load. In common with other dis ciplines, bioethics has begun to see clinical training as a con dition of didactic theory and apprenticeship. (shrink)

Three famous sophists are referred to together in the Apology of Sokrates as still practising their enviably lucrative itinerant profession in 399 B.C. (not, by implication, in Athens): Gorgias of Leontinoi, Prodikos of Keos and Hippias of Elis. The last of these was the least well known to the Athenian demos, having practised mainly in Dorian cities. There is no extant reference to him in Old Comedy, but we can assume that he was sufficiently famous - especially for his fees (...) (possibly the highest charged by any sophist) - to justify his inclusion as the third of this 'triad'; cf. the triad Protagoras - Hippias - Prodikos in the Protagoras, considered further below. Gorgias was by now a grand old man of about ninety (with more than a decade of active life still ahead of him), the last survivor of the first generation of fee-taking educators, associated first and foremost in the popular mind with the suspect arts of political and forensic persuasion. Prodikos and Hippias were probably in their sixties. (shrink)

The Hutchinsonian movement exercised considerable influence on thought about various topics of importance in England's Enlightenment/Counter-Enlightenment debates. Its epistemological stance, derived from a group of Irish writers of the early eighteenth century, places the movement at the centre of these debates and does much to explain its attraction to contemporaries. The article emphasises the persistence of Hutchinsonian thought and the continuing importance of its epistemological underpinnings into the early nineteenth century, drawing attention particularly to the writings of Bishop William Van (...) Mildert. (shrink)